OntologyTerm KBM-7

released
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   May 11th, 2017 at 4:02pm

Details

definition 
KBM-7 cells were derived from a 39-year-old man with chronic myeloid leukemia in blast crisis. The original cell line contained both near haploid and hyperdiploid clones. Subsequent subcloning yielded a pure near-haploid cell line.Genome analysis has revealed that besides the disomic chromosome 8 also a 30 megabase fragment of chromosome 15 is present in two copies. Like other CML cells lines (e.g., K562) KBM-7 cells are positive for the Philadelphia chromosome harboring the BCR-ABL oncogenic fusion. KBM-7 cells have been reprogrammed to yield the HAP1 cell line which is also haploid for chromosome 8. (EFO)
namespace 
http://www.ebi.ac.uk/efo
parents 
  1. ENCODE cell line
  2. Homo sapiens cell line
  3. chronic myelogenous leukemia cell line
preferred_name 
KBM-7
references 
  1. None
slim_terms 
  1. cell
  2. cell
source_ontologies 
  1. Experimental Factor Ontology
term_id 
EFO:0005903
term_name 
KBM-7
term_url 
http://www.ebi.ac.uk/efo/EFO_0005903